Calsyntenin
WebJul 22, 2024 · Nowadays, a large population around the world, especially the elderly, suffers from neurological inflammatory and degenerative disorders/diseases. Current drug delivery strategies are facing different challenges because of the presence of the BBB, which limits the transport of various substances and cells to brain parenchyma. Additionally, the low … WebCalsyntenin-1 is a calcium-binding protein that may regulate post-synaptic signaling and Amyloid Precursor Protein (APP) cleavage and gene activation. Notably, when …
Calsyntenin
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WebDec 7, 2024 · Here, we identify calsyntenin-3β (CLSTN3β) as a critical determinant of the multilocular LD phenotype and efficient lipid use characteristic of thermogenic adipocytes. CLSTN3β localizes to ER ... Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
WebJun 3, 2016 · For example, calsyntenin-3 is involved in synapse induction but it has not been demonstrated in vesicle transport. In addition, calsyntenin-1 and calsyntenin-2 do not interact with α-neurexin and they do not have synaptogenic activity (Pettem et al. 2013). Thus, further studies are needed for a full understanding of the physiological roles of ... WebSep 25, 2024 · Neuronal calsyntenins (Clstns), members of the cadherin superfamily, are a group of three evolutionarily conserved synapse organizers, originally identified in spinal cord neurons.
WebJul 3, 2024 · Calsyntenin-3 (Clstn3) is a postsynaptic adhesion molecule that induces presynaptic differentiation via presynaptic neurexins (Nrxns), but whether Nrxns directly … WebMar 29, 2024 · Vagnoni A, et al. Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Hum. Mol. Genet. 2012;21:2845–2854. doi: 10.1093/hmg/dds109. Gotoh, N. et al. APP amyloidogenic processing is enhanced in the brains of Alcadein α-deficient mice. Under submission. Yagi T, et al.
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WebCalsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the Clstn3 (also known as Clstn3b) gene (Gene ID: 232270) in murine species. CLSTN3β is a mammal-specific that is preferentially expressed in thermogenic adipocytes and is localized in endoplasmic reticulum. Its expression in brown adipose tissue is ... register2park towingWebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However ... problems with urination in womenWebMay 9, 2024 · The newly identified calsyntenin 3β protein has a role in the innervation of thermogenic fat through a mechanism of communication—which is unique to mammals—between thermogenic adipocytes and... register 2 ride broward countyWebJul 14, 2015 · Calsyntenin-2, also known as alcadein-γ, is a neuronal cell surface synaptic protein with an evolutionarily conserved role in learning and memory. In humans, … problems with usaa bankingWebCalsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13–16). As such, calsyntenin-1 … register 4 vip mountsinai.orgWebJun 7, 2006 · Calsyntenin-1 Is Enriched in Axonal Growth Cone Vesicles. The presence of calsyntenin-1–containing organelles in developing axons led us to presume that these organelles are targeted to the growing tips, the growth cones. To test this, we performed immunocytochemistry of cultured primary neurons using antibodies R85 and R140 … register 4520 printer with google cloud printWebApr 1, 2011 · Kinesin light chain 1 (KLC1) binds to the intracellular cytoplasmic domain of the type-1 membrane-spanning protein calsyntenin-1 (also known as alcadein-α) to mediate transport of a subset of vesicles. Here, we identify serine 460 in KLC1 (KLC1ser460) as a phosphorylation site and show that mutation of KLC1ser460 … register 2 factor authentication