WebSep 1, 2004 · Cyclic mechanical strain activates the mitogen-activated protein kinase (MAPK) pathway, promoting cell proliferation. Integrins, which act as mechanoreceptors, may activate MAPK via two major pathways, one involving focal adhesion kinase (FAK) and the other, the protein Shc. In contrast to cultured cells, exposure of intact aortas in … WebApr 2, 2024 · In the lungs, vascular endothelial cells experience cyclic mechanical strain resulting from rhythmic breathing motions and intraluminal blood pressure. Mechanical stress creates evident physiological, morphological, biochemical, and gene expression changes in vascular endothelial cells.
Current strategies of mechanical stimulation for maturation
WebThe internal stress and the mechanical quantities on cyclic deformation were empirically formulated as functions of the yield stress and the work hardening exponent in a static tension, and the dislocation density. WebMay 11, 2009 · The effects of cyclic strain on VSMC migration and the mechanisms involved are poorly understood. Application of 20% strain to cultured VSMCs enhances VSMC migration (Li et al., 2003), which suggests that mechanical strain has a modulating effect on VSMC migration. Our study showed that 10% strain inhibited VSMC migration. cee recrutement thouars
Frontiers Crosstalk Between CD11b and Piezo1 Mediates …
WebDec 1, 2013 · Cyclic mechanical strain effects have been investigated for numerous cell types such as endothelial cells [2], fibroblasts [3] and smooth muscle cells [4]. For … WebThe cyclic mechanical stress parameters used for our manufactured mechanical loading device ( Figures 1A,B) are as follows: 0.3 and 0.9% elastic strain magnitude, 5-Hz sinusoidal curve, for 30 min/day ( Chang et al., 2024 ). The specimen (a) with BMSCs cultured on the surface was placed into the fixed slot (b) and fixed. WebJun 25, 2010 · In nanotoxicology studies, this lung mimic revealed that cyclic mechanical strain accentuates toxic and inflammatory responses of the lung to silica nanoparticles. Mechanical strain also enhances epithelial and endothelial uptake of nanoparticulates and stimulates their transport into the underlying microvascular channel. but why youtube