De novo design of potent and selective mimics
WebJun 25, 2024 · Here, we review several modifications of commonly used cytokines that have been engineered to extend their half-life and increase tumor targeting, we summarize their potential issues and newer designs of engineered cytokines. INTRODUCTION Cytokines are potent immune-modulating protein molecules that are used in treating … Web1 day ago · Then, virtual screening methods (e.g., molecular docking, pharmacophore modeling, and QSAR) as well as structure- and ligand-based classical/de novo drug design were introduced and discussed.
De novo design of potent and selective mimics
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WebMay 16, 2024 · We use this strategy to design mimics of the central immune cytokine interleukin-2 (IL-2) that bind to the IL-2 receptor βγ c heterodimer (IL-2Rβγ c ) but have no binding site for IL-2Rα (also called CD25) or IL-15Rα (also known as CD215) ... WebJan 1, 2024 · This protein mimics the functions of IL-2 and IL-15 and, because Neo-2 signals independently of the IL-2Rα chain (only engaging the IL-2Rβ and γ c chains), it exhibits potent antitumor activity...
WebJul 15, 2016 · CTO and Co-founder at a new stealth biotech venture Machine Learning Cloud Computing De Novo Protein Design Seattle, … Web(see Extended Data Table 1). from publication: De novo design of potent and selective mimics of IL-2 and IL-15 We describe a de novo computational approach for designing …
WebMay 6, 2016 · De novo design of potent and selective mimics of IL-2 and IL-15. text, January 2024. Silva, Daniel-Adriano; Yu, Shawn; Ulge, Umut Y. Apollo - University of Cambridge Repository; DOI: 10.17863/cam.35821; The coming of age of de novo protein design journal, September 2016. WebSep 9, 2024 · Ten designs bound the RBD, with affinities ranging from 100 picomolar to 10 nanomolar, and blocked SARS-CoV-2 infection of Vero E6 cells with median inhibitory concentration (IC 50) values between 24 picomolar and 35 nanomolar. The most potent, with new binding modes, are 56- and 64-residue proteins (IC 50 ~ 0.16 nanograms per …
WebMar 1, 2024 · Major finding: A de novo IL2/IL15 mimic has improved antitumor activity and reduced toxicity compared with native IL2. Concept: Design of a hyperstable mimic that …
WebJan 9, 2024 · Read the paper: De novo design of potent and selective mimics of IL-2 and IL-15. IL-2 delivers its message by simultaneously … hootsuite for nonprofitsWebAbstract. We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology … hootsuite for twitterWebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, … hootsuite free plan sign upWebNov 19, 1998 · On the basis of the structure-activity relationships of delta-opioid-selective peptide ligands and on a model of the proposed bioactive conformation for a potent and … hootsuite free for nonprofitsWebNov 15, 2024 · Furthermore, our model does not need a precise backbone location, making it an attractive tool for working with de novo design of protein–protein interactions. Availability and implementation. ... De novo design of potent and selective mimics of IL-2 and IL-15. Nature, hootsuite for social listeningWebDe novo design has been used previously to support short linear epitopes34–37; here we support more complex binding interfaces by using a parametric construction of disembodied helices coupled with knowledge-based loop closure38 (Fig. 1b, c). hootsuite guiding principlesWebSci-Hub De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565 (7738), 186–191 10.1038/s41586-018-0830-7 sci hub to open science ↓ save Silva, D.-A., Yu, S., Ulge, U. Y., Spangler, J. B., Jude, K. M., Labão-Almeida, C., … Baker, D. (2024). De novo design of potent and selective mimics of IL-2 and IL-15. hootsuite healthcare