Web30 Nov 2024 · Talin, a 250-kD protein that connects β integrin cytoplasmic domains to the actin cytoskeleton, consists of a 45-kD N-terminal head (FERM) domain attached via a … Web3 Apr 2024 · Background Talin-1 as a component of multi-protein adhesion complexes plays a role in tumor formation and migration in various malignancies. This study investigated Talin-1 in protein levels as a potential prognosis biomarker in skin tumors. Methods Talin-1 was evaluated in 106 skin cancer (33 melanomas and 73 non-melanomas skin cancer …
Expression of Talin-1 in endometriosis and its possible role in ...
Web3 Oct 2003 · Talin is a major cytoskeletal protein that colocalizes with activated integrins and binds to integrin β cytoplasmic domains, and overexpression of talin's N-terminus activates integrins ().To establish whether talin is required for integrin activation, we used small interfering RNAs to knock down talin expression in cultured cells ().A Chinese … Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts. Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is found in high concentrations in focal adhesions. It is capable of linking integrins to the actin cytoskeleton either directly or indirectly by interacting with vinculin and α-actinin. thunderbolt service cannot be found alienware
Talin-1 is the principal platelet Rap1 effector of integrin activation
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