The chondrocyte
網頁The chondrocyte is the resident cell of cartilage that is a prominent tissue in the embryo acting as a template for the development of skeletal elements. In the adult, the distribution of permanent cartilage is much more restricted and is necessary for mechanical support, growth and movement. 網頁2013年12月15日 · The articular chondrocyte lives in a dynamic mechanical environment that is a complex combination of compression, shear stress, hydrostatic pressure, osmotic stress, and tensile stretch. The compression results from direct contact between joint …
The chondrocyte
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網頁Chondrocytes are the only cell type in cartilage and represent 1%–2% of the total cartilage volume. Mature articular chondrocytes do not show mitotic activity and have a low metabolism aimed to maintain an equilibrium between anabolism and catabolism processes leading to turnover of the ECM components. 網頁2024年11月15日 · Electron tomography from tilt-series data of portions of in situ chondrocyte primary cilia were first described in 2004 [3].Full tomographic 3D reconstruction of an entire cilium, from tilt-series data, was first published in 2012 [4,20].Then in 2015, Shinohara et al. [17] published beautiful 3D reconstructions of the microtubules of …
網頁2024年11月11日 · Chondrocyte isolation requires a combination of enzymatic and mechanical digestion of cartilaginous tissues in order to release the chondrocytes. Extracted primary chondrocytes will then adhere to standard tissue culture plastics, typically in small clusters, over a period of a few days in monolayer culture. Chondrocyte … 網頁2024年4月14日 · The loss of WLS specificity in cartilage resulted in delayed chondrocyte differentiation, disorganized chondrocyte arrangement, and impaired endochondral bone formation [42]. Recent studies have shown that skeletal homeostasis was altered with decreased bone formation within 1–2 weeks of conditional WLS knockout in adult mice (5 …
網頁12 小時前 · Baronas et al. paired human height GWASs with functional genome-wide screening of growth-plate chondrocytes. Targets were enriched in height heritability and genes critical for endochondral ossification. This study emphasizes that functional assays in relevant tissues can refine likely causal genes from GWASs and implicates new … Chondrocytes are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans. Although the word chondroblast is commonly used to describe an immature chondrocyte, the term is imprecise, since the … 查看更多內容 From least- to terminally-differentiated, the chondrocytic lineage is: 1. Colony-forming unit-fibroblast 2. Mesenchymal stem cell / marrow stromal cell 查看更多內容 The chondrocyte in cartilage matrix has rounded or polygonal structure. The exception occurs at tissue boundaries, for example the … 查看更多內容 • Chondrocytes in hyaline cartilage • Transmission electron micrograph of a chondrocyte, stained for calcium, showing its nucleus (N) and mitochondria (M). 查看更多內容 • Dominici M, Hofmann TJ, Horwitz EM (2001). "Bone marrow mesenchymal cells: biological properties and clinical applications". Journal of Biological Regulators and … 查看更多內容 The number of chondrocyte cells created and their maturation process can be influenced by multiple different genes and proteins. Two … 查看更多內容 • Chondronectin • Endochondral ossification • Intramembranous ossification • List of human cell types derived from the germ layers 查看更多內容 • Histology image: 03317loa – Histology Learning System at Boston University • Stem cell information 查看更多內容
網頁2024年1月14日 · This study investigated the early genetic responses of healthy in situ chondrocytes under IL-1β attack with a focus on cell cycle and calcium signaling pathways. RNA sequencing analysis identified...
網頁2014年12月12日 · In cartilage, chondrocytes are embedded within an abundant extracellular matrix (ECM). A typical chondron consists of a chondrocyte and the immediate surrounding pericellular matrix (PCM). The PCM has a patent structure, defined molecular composition, and unique physical properties that support the chondrocyte. Given this … boxcar children summer camp mystery網頁2024年4月13日 · The antler is the unique mammalian organ found to be able to regenerate completely and periodically after loss, and the continuous proliferation and differentiation of mesenchymal cells and chondrocytes together complete the regeneration of the antler. Circular non-coding RNAs (circRNAs) are considered to be important non-coding RNAs … gunsmith part 3 airwingmarine網頁2006年8月4日 · To understand the biomechanisms of the chondrocyte differentiation process, various cellular model systems have been employed, such as primary chondrocyte culture, clonal normal cell lines (HCS-2/8, Ch-1, ATDC5, CFK-2, and RCJ3.1C5.18), and transformed clonal cell lines (T/C-28a2, T/C-28a4, C-28/I2, tsT/AC62, … gunsmith part 2 mechanic網頁PMID: 8634065 DOI: 10.1002/bies.950171208 Abstract Chondrocytes are specialised cells which produce and maintain the extracellular matrix of cartilage, a tissue that is resilient and pliant. gunsmith part 3 2021網頁2002年11月1日 · On the basis of this interpretation, our results indicate that Sox9 is required for overt chondrocyte differentiation and for subsequent chondrocyte proliferation. The severe down-regulation of chondrocyte marker genes including Col2a1, Aggrecan , and Comp are in agreement with this conclusion. boxcar children x reader網頁2024年2月11日 · Chondro-induction in MSC-chondrocyte coculture is a robust process mediated by two concomitant effects: MSC-induced chondrocyte proliferation and chondrocyte-enhanced MSC chondrogenesis. The identified interactions between progenitor and mature cell populations may lead to the efficient use of freshly harvested … gunsmith part 4 eft wiki網頁2024年4月21日 · Chondrocytes are mainly responsible for the production of collagen and the extracellular matrix that will lead to the maintenance of cartilaginous tissues within joints. Initial cartilage is composed of the mesenchyme during the … boxcar children toys